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GENE INFORMATION

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Gene name

SEMA6D (HGNC Symbol)

Synonyms

FLJ11598, KIAA1479

Description

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D (HGNC Symbol)

Entrez gene summary

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]

Chromosome

15 (Chromosome progress)

Cytoband

q21.1

Chromosome location (bp)

47476298 - 48066420

Ensembl

ENSG00000137872 (version 69.37)

Entrez gene

80031

UniProt

Q8NFY4

neXtProt

NX_Q8NFY4

Antibodypedia

SEMA6D antibodies
 

PROTEIN VIEW

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 « 
 
SEMA6D-001
 
SEMA6D-002
 
SEMA6D-003
 
SEMA6D-004
 
SEMA6D-005
 
SEMA6D-006
 
SEMA6D-007
 
SEMA6D-008
 
SEMA6D-009
 
SEMA6D-010
 
SEMA6D-012
 
SEMA6D-013
 
SEMA6D-015
 
SEMA6D-016
 
SEMA6D-201
 
SEMA6D-202
 
SEMA6D-203
 
SEMA6D-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SEMA6D-001 ENSP00000452815
ENST00000558014
Q8NFY4
Show all »
Show » Show » 1011 113.3 Yes 1
SEMA6D-002 ENSP00000446152
ENST00000536845
Q8NFY4
Show all »
Show » Show » 1073 119.9 Yes 1
SEMA6D-003 ENSP00000374076
ENST00000389425
Q8NFY4
Show all »
Show » Show » 476 54.2 Yes 0
SEMA6D-004 ENSP00000324857
ENST00000316364
Q8NFY4
Show all »
Show » Show » 1073 119.9 Yes 1
SEMA6D-005 ENSP00000346786
ENST00000354744
Q8NFY4
Show all »
Show » Show » 1017 113.7 Yes 1
SEMA6D-006 ENSP00000350770
ENST00000358066
Q8NFY4
Show all »
Show » Show » 1011 113.3 Yes 1
SEMA6D-007 ENSP00000374079
ENST00000389428
Q8NFY4
Show all »
Show » Show » 998 111.7 Yes 1
SEMA6D-008 ENSP00000453661
ENST00000558816
A6NM95
Show all »
Show » Show » 597 67.5 Yes 0
SEMA6D-009 ENSP00000453097
ENST00000559184
H0YL82
Show all »
Show » Show » 22 2.5 Yes 0
SEMA6D-010 ENSP00000453420
ENST00000560636
1 0.1 No 0
SEMA6D-012 ENSP00000453530
ENST00000561133
H0YMA6
Show all »
Show » Show » 148 17.6 Yes 0
SEMA6D-013 ENSP00000453755
ENST00000559196
H0YMV0
Show all »
Show » Show » 219 25.4 Yes 0
SEMA6D-015 ENSP00000453518
ENST00000559064
54 5.8 No 0
SEMA6D-016 ENSP00000453689
ENST00000560006
Show » 198 21.8 No 1
SEMA6D-201 ENSP00000348276
ENST00000355997
A6NM95
Show all »
Show » Show » 597 67.5 Yes 0
SEMA6D-202 ENSP00000374083
ENST00000389432
Q8NFY4
Show all »
Show » Show » 1030 115.3 Yes 1
SEMA6D-203 ENSP00000374084
ENST00000389433
Q8NFY4
Show all »
Show » Show » 1054 117.9 Yes 1
SEMA6D-204 ENSP00000442040
ENST00000537942
Q8NFY4
Show all »
Show » Show » 1011 113.3 Yes 1