BCAR3

GENE INFORMATION

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Gene name

BCAR3 (HGNC Symbol)

Synonyms

NSP2, SH2D3B

Description

Breast cancer anti-estrogen resistance 3 (HGNC Symbol)

Entrez gene summary

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

1

Cytoband

p22.1

Chromosome location (bp)

94027347 - 94312706

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137936 (version 75.37)

Entrez gene

8412

UniProt

O75815 (UniProt - Evidence at protein level)

neXtProt

NX_O75815

Antibodypedia

BCAR3 antibodies
 

PROTEIN VIEW

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BCAR3-001
 
BCAR3-002
 
BCAR3-003
 
BCAR3-004
 
BCAR3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCAR3-001 ENSP00000260502
ENST00000260502
O75815
Show all »
Show » Show » 825 92.6 No 0
BCAR3-002 ENSP00000359263
ENST00000370243
O75815
Show all »
Show » Show » 825 92.6 No 0
BCAR3-003 ENSP00000359264
ENST00000370244
O75815
Show all »
Show » Show » 825 92.6 No 0
BCAR3-004 ENSP00000359267
ENST00000370247
O75815
Show all »
Show » Show » 734 82.4 No 0
BCAR3-201 ENSP00000441343
ENST00000539242
O75815
Show all »
Show » Show » 501 55.7 No 0