PPM1B

GENE INFORMATION

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Gene name

PPM1B (HGNC Symbol)

Synonyms

PP2CB, PP2CBETA, PPC2BETAX

Description

protein phosphatase, Mg2+/Mn2+ dependent, 1B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p21

Chromosome location (bp)

44395108 - 44471523

Ensembl

ENSG00000138032 (version 73.37)

Entrez gene

5495

UniProt

O75688 (UniProt - Evidence at protein level)

neXtProt

NX_O75688

Antibodypedia

PPM1B antibodies
 

PROTEIN VIEW

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PPM1B-001
 
PPM1B-002
 
PPM1B-003
 
PPM1B-004
 
PPM1B-005
 
PPM1B-011
 
PPM1B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPM1B-001 ENSP00000282412
ENST00000282412
O75688
Show all »
Show » Show » 479 52.6 No 0
PPM1B-002 ENSP00000367813
ENST00000378551
O75688
Show all »
Show » Show » 387 42.8 No 0
PPM1B-003 ENSP00000326089
ENST00000345249
O75688
Show all »
Show » Show » 192 20.8 No 0
PPM1B-004 ENSP00000387287
ENST00000409432
O75688
Show all »
Show » Show » 380 42.1 No 0
PPM1B-005 ENSP00000390087
ENST00000419807
C9JIR6
Show all »
Show » 378 41.8 No 0
PPM1B-011 ENSP00000386982
ENST00000409473
B8ZZF0
Show all »
Show » 303 33.2 No 0
PPM1B-201 ENSP00000387341
ENST00000409895
O75688
Show all »
Show » Show » 327 36.3 No 0