LHCGR

GENERAL INFORMATION

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Gene name

LHCGR

Gene description

Luteinizing hormone/choriogonadotropin receptor

Protein class

Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (ovary)

Protein evidence

Evidence at protein level

Protein localization

RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
CAB009814
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (ovary)

Organ

Expression



GENE INFORMATION

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Gene name

LHCGR (HGNC Symbol)

Synonyms

HHG, LCGR, LGR2, LHR, ULG5

Description

Luteinizing hormone/choriogonadotropin receptor (HGNC Symbol)

Entrez gene summary

This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p16.3

Chromosome location (bp)

48686775 - 48755730

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138039 (version 78.38)

Entrez gene

3973

UniProt

P22888 (UniProt - Evidence at protein level)

neXtProt

NX_P22888

Antibodypedia

LHCGR antibodies


PROTEIN BROWSER

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ENST00000294954
 
ENST00000401907
 
ENST00000403273
 
ENST00000405626
 
ENST00000428232
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LHCGR-001 ENSP00000294954
ENST00000294954
P22888
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Show » Show » 699 78.6 Yes 7
LHCGR-003 ENSP00000386033
ENST00000405626
E7ENI1
Show all »
Show » Show » 672 75.5 Yes 7
LHCGR-004 ENSP00000385847
ENST00000403273
E7ESK4
Show all »
Show » Show » 329 36.5 Yes 0
LHCGR-006 ENSP00000385406
ENST00000401907
E7EQB5
Show all »
Show » Show » 325 36.3 Yes 0
LHCGR-007 ENSP00000403748
ENST00000428232
H7C226
Show all »
Show » Show » 175 19.8 No 0