CYP1B1

GENE INFORMATION

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Gene name

CYP1B1 (HGNC Symbol)

Synonyms

CP1B, GLC3A

Description

cytochrome P450, family 1, subfamily B, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p22.2

Chromosome location (bp)

38294116 - 38337044

Ensembl

ENSG00000138061 (version 73.37)

Entrez gene

1545

UniProt

Q16678 (UniProt - Evidence at protein level)

neXtProt

NX_Q16678

Antibodypedia

CYP1B1 antibodies
 

PROTEIN VIEW

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CYP1B1-001
 
CYP1B1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP1B1-001 ENSP00000260630
ENST00000260630
Q16678
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Show » Show » 543 60.8 No 2
CYP1B1-003 ENSP00000384972
ENST00000407341
Q16678
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Show » Show » 543 60.8 No 2