ABCG5

GENE INFORMATION

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Gene name

ABCG5 (HGNC Symbol)

Synonyms

STSL

Description

ATP-binding cassette, sub-family G (WHITE), member 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p21

Chromosome location (bp)

44039611 - 44066004

Ensembl

ENSG00000138075 (version 73.37)

Entrez gene

64240

UniProt

Q9H222 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H222

Antibodypedia

ABCG5 antibodies
 

PROTEIN VIEW

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ABCG5-001
 
ABCG5-002
 
ABCG5-003
 
ABCG5-004
 
ABCG5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCG5-001 ENSP00000260645
ENST00000260645
Q9H222
Show all »
Show » Show » 651 72.5 No 6
ABCG5-002 ENSP00000384513
ENST00000405322
E7EX35
Show all »
Show » Show » 480 53.4 No 6
ABCG5-003 ENSP00000430935
ENST00000486512
E5RHB7
Show all »
Show » 118 12.8 No 0
ABCG5-004 ENSP00000386501
ENST00000409962
E5RFY8
Show all »
Show » 132 14.4 No 0
ABCG5-201 ENSP00000445107
ENST00000543989
Q2T9G2
Show all »
Show » Show » 256 28.5 Yes 5