CYP2C9

GENERAL INFORMATION

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Gene name

CYP2C9

Gene description

Cytochrome P450, family 2, subfamily C, polypeptide 9

Protein class

Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in hepatocytes and gastrointestinal tract.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Supportive based on 2 antibodies.
HPA015066 , CAB016123
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression



GENE INFORMATION

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Gene name

CYP2C9 (HGNC Symbol)

Synonyms

CYP2C10, P450IIC9

Description

Cytochrome P450, family 2, subfamily C, polypeptide 9 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q23.33

Chromosome location (bp)

94938658 - 94989390

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138109 (version 78.38)

Entrez gene

1559

UniProt

P11712 (UniProt - Evidence at protein level)

neXtProt

NX_P11712

Antibodypedia

CYP2C9 antibodies


PROTEIN BROWSER

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ENST00000260682
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP2C9-001 ENSP00000260682
ENST00000260682
P11712
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