CYP2C8

GENE INFORMATION

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Gene name

CYP2C8 (HGNC Symbol)

Synonyms

CPC8

Description

cytochrome P450, family 2, subfamily C, polypeptide 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Chromosome

10 (Chromosome progress)

Cytoband

q23.33

Chromosome location (bp)

96796530 - 96829254

Ensembl

ENSG00000138115 (version 73.37)

Entrez gene

1558

UniProt

P10632 (UniProt - Evidence at protein level)

neXtProt

NX_P10632

Antibodypedia

CYP2C8 antibodies
 

PROTEIN VIEW

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CYP2C8-001
 
CYP2C8-003
 
CYP2C8-007
 
CYP2C8-008
 
CYP2C8-201
 
CYP2C8-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP2C8-001 ENSP00000360317
ENST00000371270
P10632
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Show » Show » 490 55.8 Yes 0
CYP2C8-003 ENSP00000433191
ENST00000527420
G3V188
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Show » Show » 393 45 Yes 0
CYP2C8-007 ENSP00000433842
ENST00000525991
E9PIW6
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Show » Show » 99 11.4 Yes 0
CYP2C8-008 ENSP00000433314
ENST00000490994
E9PLI9
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Show » Show » 83 9.3 Yes 0
CYP2C8-201 ENSP00000445062
ENST00000535898
P10632
Show all »
Show » Show » 388 44.4 No 0
CYP2C8-202 ENSP00000442343
ENST00000539050
F5H7Q9
Show all »
Show » Show » 307 35.3 No 0