ANXA7

GENE INFORMATION

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Gene name

ANXA7 (HGNC Symbol)

Synonyms

ANX7

Description

annexin A7 (HGNC Symbol)

Entrez gene summary

Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

75135203 - 75173834

Ensembl

ENSG00000138279 (version 73.37)

Entrez gene

310

UniProt

P20073 (UniProt - Evidence at protein level)

neXtProt

NX_P20073

Antibodypedia

ANXA7 antibodies
 

PROTEIN VIEW

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ANXA7-001
 
ANXA7-002
 
ANXA7-005
 
ANXA7-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANXA7-001 ENSP00000362012
ENST00000372921
P20073
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Show » Show » 466 50.3 No 0
ANXA7-002 ENSP00000362010
ENST00000372919
P20073
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Show » Show » 488 52.7 No 0
ANXA7-005 ENSP00000378317
ENST00000394847
B9ZVT2
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Show » 144 14 No 0
ANXA7-201 ENSP00000442864
ENST00000535178
B4DT77
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Show » 336 37.8 No 0