ADAMTS14

GENE INFORMATION

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Gene name

ADAMTS14

Synonyms

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 14 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

72432559 - 72522197

Ensembl

ENSG00000138316 (version 73.37)

Entrez gene

140766

UniProt

Q8WXS8 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8WXS8

Antibodypedia

ADAMTS14 antibodies
 

PROTEIN VIEW

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ADAMTS14-001
 
ADAMTS14-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS14-001 ENSP00000362304
ENST00000373208
Q8WXS8
Show all »
Show » Show » 1226 134.2 Yes 0
ADAMTS14-002 ENSP00000362303
ENST00000373207
Q8WXS8
Show all »
Show » Show » 1223 133.9 Yes 0