ATIC

GENE INFORMATION

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Gene name

ATIC (HGNC Symbol)

Synonyms

AICARFT, IMPCHASE, PURH

Description

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (HGNC Symbol)

Entrez gene summary

This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]

Chromosome

2 (Chromosome progress)

Cytoband

q35

Chromosome location (bp)

216176540 - 216214487

Ensembl

ENSG00000138363 (version 73.37)

Entrez gene

471

UniProt

P31939 (UniProt - Evidence at protein level)

neXtProt

NX_P31939

Antibodypedia

ATIC antibodies
 

PROTEIN VIEW

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ATIC-001
 
ATIC-002
 
ATIC-004
 
ATIC-007
 
ATIC-008
 
ATIC-009
 
ATIC-012
 
ATIC-013
 
ATIC-015
 
ATIC-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATIC-001 ENSP00000236959
ENST00000236959
P31939
Show all »
Show » Show » 592 64.6 No 0
ATIC-002 ENSP00000406792
ENST00000443953
F2Z3E8
Show all »
Show » 43 4.6 No 0
ATIC-004 ENSP00000388675
ENST00000444305
F8WEF0
Show all »
Show » Show » 84 8.6 No 0
ATIC-007 ENSP00000415935
ENST00000435675
E9PBU3
Show all »
Show » Show » 591 64.5 No 0
ATIC-008 ENSP00000394317
ENST00000427397
F2Z3E8
Show all »
Show » 43 4.6 No 0
ATIC-009 ENSP00000402393
ENST00000413174
C9JLK0
Show all »
Show » Show » 170 18.8 No 0
ATIC-012 ENSP00000393485
ENST00000446622
Show » Show » 200 22 No 0
ATIC-013 ENSP00000401936
ENST00000426233
Show » Show » 231 25.9 No 0
ATIC-015 ENSP00000391399
ENST00000442048
H7BZU3
Show all »
Show » Show » 107 12.2 No 0
ATIC-201 ENSP00000440523
ENST00000540518
F5GWY2
Show all »
Show » Show » 533 58.6 No 0