IDH1

GENE INFORMATION

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Gene name

IDH1

Synonyms

Description

isocitrate dehydrogenase 1 (NADP+), soluble (HGNC Symbol)

Entrez gene summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

2 (Chromosome progress)

Cytoband

q34

Chromosome location (bp)

209100951 - 209130798

Ensembl

ENSG00000138413 (version 73.37)

Entrez gene

3417

UniProt

O75874 (UniProt - Evidence at protein level)

neXtProt

NX_O75874

Antibodypedia

IDH1 antibodies
 

PROTEIN VIEW

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IDH1-001
 
IDH1-004
 
IDH1-006
 
IDH1-007
 
IDH1-008
 
IDH1-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IDH1-001 ENSP00000260985
ENST00000345146
O75874
Show all »
Show » Show » 414 46.7 No 0
IDH1-004 ENSP00000410513
ENST00000446179
O75874
Show all »
Show » Show » 414 46.7 No 0
IDH1-006 ENSP00000390265
ENST00000415913
O75874
Show all »
Show » Show » 414 46.7 No 0
IDH1-007 ENSP00000396787
ENST00000451391
C9JJE5
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Show » 62 7.1 No 0
IDH1-008 ENSP00000409045
ENST00000417583
C9JLU6
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Show » 74 8.3 No 0
IDH1-009 ENSP00000391075
ENST00000415282
C9J4N6
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Show » 157 17.7 No 0