SPPL2A

GENE INFORMATION

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Gene name

SPPL2A (HGNC Symbol)

Synonyms

IMP3, PSL2

Description

signal peptide peptidase like 2A (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012]

Chromosome

15 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

50999506 - 51058005

Ensembl

ENSG00000138600 (version 73.37)

Entrez gene

84888

UniProt

Q8TCT8 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TCT8

Antibodypedia

SPPL2A antibodies
 

PROTEIN VIEW

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SPPL2A-001
 
SPPL2A-003
 
SPPL2A-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPPL2A-001 ENSP00000261854
ENST00000261854
Q8TCT8
Show all »
Show » Show » 520 58.1 Yes 9
SPPL2A-003 ENSP00000453932
ENST00000558414
H0YNA7
Show all »
Show » Show » 150 16.5 No 1
SPPL2A-004 ENSP00000453927
ENST00000558934
Show » Show » 356 40 No 8