APH1B

GENE INFORMATION

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Gene name

APH1B (HGNC Symbol)

Synonyms

APH-1B, DKFZp564D0372, PSFL

Description

APH1B gamma secretase subunit (HGNC Symbol)

Entrez gene summary

This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]

Chromosome

15 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

63568217 - 63601325

Ensembl

ENSG00000138613 (version 73.37)

Entrez gene

83464

UniProt

Q8WW43 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WW43

Antibodypedia

APH1B antibodies
 

PROTEIN VIEW

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APH1B-001
 
APH1B-002
 
APH1B-003
 
APH1B-004
 
APH1B-005
 
APH1B-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APH1B-001 ENSP00000261879
ENST00000261879
Q8WW43
Show all »
Show » Show » 257 28.5 No 6
APH1B-002 ENSP00000369700
ENST00000380343
Q8WW43
Show all »
Show » Show » 216 24.3 No 5
APH1B-003 ENSP00000369697
ENST00000380340
Q4R1J8
Show all »
Show » Show » 81 8.6 No 0
APH1B-004 ENSP00000453516
ENST00000559971
19 2.2 No 0
APH1B-005 ENSP00000453327
ENST00000560353
H0YLT0
Show all »
Show » Show » 222 24.3 No 3
APH1B-006 ENSP00000453002
ENST00000560890
H0YKZ9
Show all »
Show » Show » 189 20.8 No 5