BMPR1B

GENE INFORMATION

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Gene name

BMPR1B (HGNC Symbol)

Synonyms

ALK6, CDw293

Description

bone morphogenetic protein receptor, type IB (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

4 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

95679119 - 96079599

Ensembl

ENSG00000138696 (version 73.37)

Entrez gene

658

UniProt

O00238 (UniProt - Evidence at protein level)

neXtProt

NX_O00238

Antibodypedia

BMPR1B antibodies
 

PROTEIN VIEW

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BMPR1B-001
 
BMPR1B-002
 
BMPR1B-003
 
BMPR1B-004
 
BMPR1B-005
 
BMPR1B-006
 
BMPR1B-007
 
BMPR1B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BMPR1B-001 ENSP00000426617
ENST00000515059
O00238
Show all »
Show » Show » 502 56.9 No 1
BMPR1B-002 ENSP00000378389
ENST00000394931
O00238
Show all »
Show » Show » 502 56.9 No 1
BMPR1B-003 ENSP00000264568
ENST00000264568
O00238
Show all »
Show » Show » 502 56.9 No 1
BMPR1B-004 ENSP00000421144
ENST00000506363
D6RGW8
Show all »
Show » 125 13.9 No 0
BMPR1B-005 ENSP00000425444
ENST00000512312
O00238
Show all »
Show » Show » 502 56.9 No 1
BMPR1B-006 ENSP00000424693
ENST00000502683
D6RAW8
Show all »
Show » 114 12.5 No 0
BMPR1B-007 ENSP00000421671
ENST00000509540
O00238
Show all »
Show » Show » 502 56.9 No 1
BMPR1B-201 ENSP00000401907
ENST00000440890
O00238
Show all »
Show » Show » 532 60.6 No 1