SCARB2

GENE INFORMATION

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Gene name

SCARB2 (HGNC Symbol)

Synonyms

CD36L2, HLGP85, LIMP-2, LIMPII, SR-BII

Description

scavenger receptor class B, member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Chromosome

4 (Chromosome progress)

Cytoband

q21.1

Chromosome location (bp)

77079890 - 77135046

Ensembl

ENSG00000138760 (version 73.37)

Entrez gene

950

UniProt

Q14108 (UniProt - Evidence at protein level)

neXtProt

NX_Q14108

Antibodypedia

SCARB2 antibodies
 

PROTEIN VIEW

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SCARB2-001
 
SCARB2-002
 
SCARB2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCARB2-001 ENSP00000264896
ENST00000264896
Q14108
Show all »
Show » Show » 478 54.3 Yes 1
SCARB2-002 ENSP00000399154
ENST00000452464
Q14108
Show all »
Show » Show » 335 37.8 Yes 1
SCARB2-003 ENSP00000420988
ENST00000509994
D6RDG0
Show all »
Show » Show » 106 12.1 Yes 0