CASP6

GENE INFORMATION

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Gene name

CASP6 (HGNC Symbol)

Synonyms

MCH2

Description

caspase 6, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q25

Chromosome location (bp)

110609785 - 110624739

Ensembl

ENSG00000138794 (version 73.37)

Entrez gene

839

UniProt

P55212 (UniProt - Evidence at protein level)

neXtProt

NX_P55212

Antibodypedia

CASP6 antibodies
 

PROTEIN VIEW

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CASP6-001
 
CASP6-002
 
CASP6-003
 
CASP6-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP6-001 ENSP00000265164
ENST00000265164
P55212
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Show » Show » 293 33.3 No 0
CASP6-002 ENSP00000285333
ENST00000352981
P55212
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Show » Show » 204 22.6 No 0
CASP6-003 ENSP00000424080
ENST00000505486
D6RBM3
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Show » 80 9.4 No 0
CASP6-004 ENSP00000427669
ENST00000503684
D6RHU3
Show all »
Show » 143 16.7 No 0