SLC39A8

GENERAL INFORMATION

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Gene name

SLC39A8

Gene description

Solute carrier family 39 (zinc transporter), member 8

Protein class

Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic and membranous expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 2 antibodies.
HPA038832 , HPA038833
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression



GENE INFORMATION

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Gene name

SLC39A8 (HGNC Symbol)

Synonyms

BIGM103

Description

Solute carrier family 39 (zinc transporter), member 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]

Chromosome

4

Cytoband

q24

Chromosome location (bp)

102251041 - 102431258

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138821 (version 78.38)

Entrez gene

64116

UniProt

Q9C0K1 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9C0K1

Antibodypedia

SLC39A8 antibodies


PROTEIN BROWSER

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ENST00000356736
 
ENST00000394833
 
ENST00000424970
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC39A8-001 ENSP00000349174
ENST00000356736
Q9C0K1
Show all »
Show » Show » 460 49.6 Yes 6
SLC39A8-002 ENSP00000378310
ENST00000394833
Q9C0K1
Show all »
Show » Show » 460 49.6 Yes 6
SLC39A8-003 ENSP00000394548
ENST00000424970
Q9C0K1
Show all »
Show » Show » 444 48.1 Yes 5