CD27

GENE INFORMATION

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Gene name

CD27 (HGNC Symbol)

Synonyms

S152, TNFRSF7, Tp55

Description

CD27 molecule (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

p13.31

Chromosome location (bp)

6554033 - 6560884

Ensembl

ENSG00000139193 (version 73.37)

Entrez gene

939

UniProt

P26842 (UniProt - Evidence at protein level)

neXtProt

NX_P26842

Antibodypedia

CD27 antibodies
 

PROTEIN VIEW

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CD27-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD27-001 ENSP00000266557
ENST00000266557
P26842
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