ASCL1

GENE INFORMATION

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Gene name

ASCL1 (HGNC Symbol)

Synonyms

ASH1, bHLHa46, HASH1

Description

achaete-scute complex homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

q23.2

Chromosome location (bp)

103351464 - 103354294

Ensembl

ENSG00000139352 (version 73.37)

Entrez gene

429

UniProt

P50553 (UniProt - Evidence at protein level)

neXtProt

NX_P50553

Antibodypedia

ASCL1 antibodies
 

PROTEIN VIEW

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ASCL1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASCL1-001 ENSP00000266744
ENST00000266744
P50553
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