PDX1

GENE INFORMATION

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Gene name

PDX1 (HGNC Symbol)

Synonyms

IDX-1, IPF1, MODY4, PDX-1, STF-1

Description

pancreatic and duodenal homeobox 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]

Chromosome

13 (Chromosome progress)

Cytoband

q12.2

Chromosome location (bp)

28494157 - 28500368

Ensembl

ENSG00000139515 (version 73.37)

Entrez gene

3651

UniProt

P52945 (UniProt - Evidence at protein level)

neXtProt

NX_P52945

Antibodypedia

PDX1 antibodies
 

PROTEIN VIEW

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PDX1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDX1-001 ENSP00000370421
ENST00000381033
P52945
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