MAP3K12

GENE INFORMATION

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Gene name

MAP3K12 (HGNC Symbol)

Synonyms

DLK, MEKK12, MUK, ZPK, ZPKP1

Description

mitogen-activated protein kinase kinase kinase 12 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

Chromosome

12 (Chromosome progress)

Cytoband

q13.13

Chromosome location (bp)

53874274 - 53893847

Ensembl

ENSG00000139625 (version 73.37)

Entrez gene

7786

UniProt

Q12852 (UniProt - Evidence at protein level)

neXtProt

NX_Q12852

Antibodypedia

MAP3K12 antibodies
 

PROTEIN VIEW

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MAP3K12-001
 
MAP3K12-002
 
MAP3K12-004
 
MAP3K12-005
 
MAP3K12-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K12-001 ENSP00000447889
ENST00000552365
F8VUG4
Show all »
Show » 393 43.5 No 0
MAP3K12-002 ENSP00000449038
ENST00000547488
Q12852
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Show » Show » 892 96.3 No 0
MAP3K12-004 ENSP00000267079
ENST00000267079
Q12852
Show all »
Show » Show » 859 93.2 No 0
MAP3K12-005 ENSP00000448689
ENST00000547035
Q12852
Show all »
Show » Show » 892 96.3 No 0
MAP3K12-007 ENSP00000454355
ENST00000548565
H3BMF0
Show all »
Show » 25 2.6 No 0