DUOXA1

GENE INFORMATION

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Gene name

DUOXA1 (HGNC Symbol)

Synonyms

FLJ32334, mol, NIP, NUMBIP

Description

Dual oxidase maturation factor 1 (HGNC Symbol)

Entrez gene summary

Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Chromosome

15

Cytoband

q21.1

Chromosome location (bp)

45409569 - 45422136

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140254 (version 75.37)

Entrez gene

90527

UniProt

Q1HG43 (UniProt - Evidence at protein level)

neXtProt

NX_Q1HG43

Antibodypedia

DUOXA1 antibodies
 

PROTEIN VIEW

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 « 
 
DUOXA1-001
 
DUOXA1-002
 
DUOXA1-003
 
DUOXA1-004
 
DUOXA1-005
 
DUOXA1-006
 
DUOXA1-007
 
DUOXA1-008
 
DUOXA1-009
 
DUOXA1-011
 
DUOXA1-012
 
DUOXA1-014
 
DUOXA1-015
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUOXA1-001 ENSP00000267803
ENST00000267803
Q1HG43
Show all »
Show » Show » 483 53.5 No 5
DUOXA1-002 ENSP00000453569
ENST00000559014
Q1HG43
Show all »
Show » Show » 483 53.5 No 5
DUOXA1-003 ENSP00000453836
ENST00000558422
Q1HG43
Show all »
Show » Show » 298 33.1 No 5
DUOXA1-004 ENSP00000454019
ENST00000558996
Q1HG43
Show all »
Show » Show » 298 33.1 No 5
DUOXA1-005 ENSP00000454084
ENST00000560572
Q1HG43
Show all »
Show » Show » 343 37.8 No 5
DUOXA1-006 ENSP00000415512
ENST00000430224
B5M0C0
Show all »
Show » Show » 438 48.8 No 5
DUOXA1-007 ENSP00000453614
ENST00000559013
Show » Show » 166 18.3 No 2
DUOXA1-008 ENSP00000452795
ENST00000559644
Show » 16 1.7 No 0
DUOXA1-009 ENSP00000453295
ENST00000558377
H0YLQ4
Show all »
Show » Show » 72 7.9 No 2
DUOXA1-011 ENSP00000454117
ENST00000558326
H0YNR1
Show all »
Show » Show » 77 8.4 No 2
DUOXA1-012 ENSP00000452782
ENST00000559226
H0YKF3
Show all »
Show » Show » 72 7.8 No 2
DUOXA1-014 ENSP00000453809
ENST00000559988
H0YMZ8
Show all »
Show » Show » 121 13 No 2
DUOXA1-015 ENSP00000453217
ENST00000558851
Show » 13 1.4 No 0