DUOXA1

GENERAL INFORMATION

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Gene name

DUOXA1

Gene description

Dual oxidase maturation factor 1

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

13
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (esophagus, skin, thyroid gland)
GTEx:Tissue enhanced (esophagus, thyroid gland)

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed moderate cytoplasmic and membranous positivity. Renal tubules, adrenal cortex, urothelium, uterine glands, trophoblasts and striated muscle showed strong staining. Additional nuclear staining was observed in squamous epithelia, seminiferous ducts, bone marrow poietic cells and urothelium.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA041578
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (esophagus, skin, thyroid gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (esophagus, thyroid gland)

Organ

Expression



GENE INFORMATION

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Gene name

DUOXA1 (HGNC Symbol)

Synonyms

FLJ32334, mol, NIP, NUMBIP

Description

Dual oxidase maturation factor 1 (HGNC Symbol)

Entrez gene summary

Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Chromosome

15

Cytoband

q21.1

Chromosome location (bp)

45117367 - 45129938

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140254 (version 78.38)

Entrez gene

90527

UniProt

Q1HG43 (UniProt - Evidence at protein level)

neXtProt

NX_Q1HG43

Antibodypedia

DUOXA1 antibodies


PROTEIN BROWSER

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ENST00000267803
 
ENST00000430224
 
ENST00000558326
 
ENST00000558377
 
ENST00000558422
 
ENST00000558851
 
ENST00000558996
 
ENST00000559014
 
ENST00000559226
 
ENST00000559644
 
ENST00000559988
 
ENST00000560572
 
ENST00000613425
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUOXA1-001 ENSP00000267803
ENST00000267803
Q1HG43
Show all »
Show » Show » 483 53.5 No 5
DUOXA1-002 ENSP00000453569
ENST00000559014
Q1HG43
Show all »
Show » Show » 483 53.5 No 5
DUOXA1-003 ENSP00000453836
ENST00000558422
Q1HG43
Show all »
Show » Show » 298 33.1 No 5
DUOXA1-004 ENSP00000454019
ENST00000558996
Q1HG43
Show all »
Show » Show » 298 33.1 No 5
DUOXA1-005 ENSP00000454084
ENST00000560572
Q1HG43
Show all »
Show » Show » 343 37.8 No 5
DUOXA1-006 ENSP00000415512
ENST00000430224
B5M0C0
Show all »
Show » Show » 438 48.8 No 5
DUOXA1-008 ENSP00000452795
ENST00000559644
Show » 16 1.7 No 0
DUOXA1-009 ENSP00000453295
ENST00000558377
H0YLQ4
Show all »
Show » Show » 72 7.9 No 2
DUOXA1-011 ENSP00000454117
ENST00000558326
H0YNR1
Show all »
Show » Show » 77 8.4 No 2
DUOXA1-012 ENSP00000452782
ENST00000559226
H0YKF3
Show all »
Show » Show » 72 7.8 No 2
DUOXA1-014 ENSP00000453809
ENST00000559988
H0YMZ8
Show all »
Show » Show » 121 13 No 2
DUOXA1-015 ENSP00000453217
ENST00000558851
Show » 13 1.4 No 0
DUOXA1-201 ENSP00000480154
ENST00000613425
B5M0C0
Show all »
Show » Show » 438 48.8 No 5