The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Prostate cancers showed strong cytoplasmic staining. Several cases of duct carcinoma of breast, papillary adenocarcinomas of thyroid and endometrial cancers displayed moderate to strong positivity. Remaining malignant cells were negative.
Prostate cancers along with a few cases of hepatocellular carcinomas, breast and endometrial cancers showed strong cytoplasmic and occasional nuclear positivity. Malignant lymphomas, melanomas and several cases of ovarian, skin and testicular cancers were negative. The remaining malignant cells displayed weak to moderate cytoplasmic and/or nuclear immunoreactivity.
Validation
Two (or more) antibodies yielding similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
