BCL2A1

GENERAL INFORMATION

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Gene name

BCL2A1

Gene description

BCL2-related protein A1

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (bone marrow)
GTEx:Tissue enhanced (lung, spleen)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

BCL2A1 (HGNC Symbol)

Synonyms

ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1

Description

BCL2-related protein A1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q25.1

Chromosome location (bp)

79960889 - 79971446

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140379 (version 78.38)

Entrez gene

597

UniProt

Q16548 (UniProt - Evidence at protein level)

neXtProt

NX_Q16548

Antibodypedia

BCL2A1 antibodies


PROTEIN BROWSER

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ENST00000267953
 
ENST00000335661
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL2A1-001 ENSP00000267953
ENST00000267953
Q16548
Show all »
Show » Show » 175 20.1 No 0
BCL2A1-002 ENSP00000335250
ENST00000335661
Q16548
Show all »
Show » Show » 163 18.7 No 0