TPM1

GENE INFORMATION

? »

Gene name

TPM1 (HGNC Symbol)

Synonyms

C15orf13, CMH3

Description

tropomyosin 1 (alpha) (HGNC Symbol)

Entrez gene summary

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

63334831 - 63364114

Ensembl

ENSG00000140416 (version 73.37)

Entrez gene

7168

UniProt

P09493 (UniProt - Evidence at protein level)

neXtProt

NX_P09493

Antibodypedia

TPM1 antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
TPM1-001
 
TPM1-002
 
TPM1-003
 
TPM1-005
 
TPM1-008
 
TPM1-009
 
TPM1-010
 
TPM1-011
 
TPM1-012
 
TPM1-013
 
TPM1-014
 
TPM1-015
 
TPM1-016
 
TPM1-017
 
TPM1-018
 
TPM1-019
 
TPM1-020
 
TPM1-022
 
TPM1-023
 
TPM1-024
 
TPM1-027
 
TPM1-028
 
TPM1-029
 
TPM1-033
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPM1-001 ENSP00000288398
ENST00000288398
P09493
Show all »
Show » Show » 284 32.9 No 0
TPM1-002 ENSP00000385107
ENST00000403994
P09493
Show all »
Show » Show » 284 32.7 No 0
TPM1-003 ENSP00000453062
ENST00000560970
265 30.4 No 0
TPM1-005 ENSP00000267996
ENST00000267996
P09493
Show all »
Show » Show » 284 32.7 No 0
TPM1-008 ENSP00000350667
ENST00000357980
Q6ZN40
Show all »
Show » 326 37.5 No 0
TPM1-009 ENSP00000452887
ENST00000558347
H0YKP3
Show all »
157 17.9 No 0
TPM1-010 ENSP00000452879
ENST00000559397
P09493
Show all »
Show » Show » 284 32.8 No 0
TPM1-011 ENSP00000334624
ENST00000334895
P09493
Show all »
Show » Show » 245 28.4 No 0
TPM1-012 ENSP00000384315
ENST00000404484
H7BYY1
Show all »
Show » 248 28.7 No 0
TPM1-013 ENSP00000453817
ENST00000558544
H0YN06
Show all »
49 5.7 No 0
TPM1-014 ENSP00000453724
ENST00000560959
B7Z596
Show all »
Show » Show » 275 31.8 No 1
TPM1-015 ENSP00000452658
ENST00000559281
H0YK48
Show all »
Show » 248 28.6 No 0
TPM1-016 ENSP00000322577
ENST00000317516
F5H7S3
Show all »
Show » 245 28.5 No 0
TPM1-017 ENSP00000452624
ENST00000558264
H0YK20
Show all »
92 10.8 No 0
TPM1-018 ENSP00000351022
ENST00000358278
P09493
Show all »
Show » Show » 284 32.9 No 0
TPM1-019 ENSP00000452999
ENST00000560445
H0YKZ6
Show all »
70 8 No 0
TPM1-020 ENSP00000453324
ENST00000561425
H0YLS7
Show all »
40 4.7 No 0
TPM1-022 ENSP00000453050
ENST00000560615
H0YL42
Show all »
Show » 108 12.8 No 0
TPM1-023 ENSP00000452830
ENST00000558910
33 3.7 No 0
TPM1-024 ENSP00000453136
ENST00000560679
8 0.9 No 0
TPM1-027 ENSP00000453955
ENST00000561266
223 25.5 No 0
TPM1-028 ENSP00000453941
ENST00000559556
P09493
Show all »
Show » Show » 284 32.7 No 0
TPM1-029 ENSP00000452977
ENST00000559831
H0YKX5
Show all »
142 16.4 No 0
TPM1-033 ENSP00000453092
ENST00000561395
H0YL80
Show all »
68 8 No 0