IGF1R

GENE INFORMATION

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Gene name

IGF1R (HGNC Symbol)

Synonyms

CD221, IGFIR, IGFR, JTK13, MGC18216

Description

insulin-like growth factor 1 receptor (HGNC Symbol)

Entrez gene summary

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q26.3

Chromosome location (bp)

99192200 - 99507759

Ensembl

ENSG00000140443 (version 73.37)

Entrez gene

3480

UniProt

P08069 (UniProt - Evidence at protein level)

neXtProt

NX_P08069

Antibodypedia

IGF1R antibodies
 

PROTEIN VIEW

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IGF1R-001
 
IGF1R-002
 
IGF1R-004
 
IGF1R-011
 
IGF1R-016
 
IGF1R-017
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGF1R-001 ENSP00000268035
ENST00000268035
P08069
Show all »
Show » Show » 1367 154.8 Yes 1
IGF1R-002 ENSP00000453007
ENST00000558762
C9J5X1
Show all »
Show » Show » 1366 154.8 Yes 1
IGF1R-004 ENSP00000453180
ENST00000560972
H0YLE7
Show all »
Show » 103 11.1 No 1
IGF1R-011 ENSP00000454115
ENST00000558898
H0YNR0
Show all »
Show » 212 24.2 No 0
IGF1R-016 ENSP00000456950
ENST00000560144
90 10.1 No 0
IGF1R-017 ENSP00000453630
ENST00000558355
H0YMJ5
Show all »
Show » 190 21.3 No 0