CYP11A1

GENE INFORMATION

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Gene name

CYP11A1 (HGNC Symbol)

Synonyms

CYP11A, P450SCC

Description

cytochrome P450, family 11, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q24.1

Chromosome location (bp)

74630100 - 74660081

Ensembl

ENSG00000140459 (version 73.37)

Entrez gene

1583

UniProt

P05108 (UniProt - Evidence at protein level)

neXtProt

NX_P05108

Antibodypedia

CYP11A1 antibodies
 

PROTEIN VIEW

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CYP11A1-001
 
CYP11A1-002
 
CYP11A1-004
 
CYP11A1-006
 
CYP11A1-008
 
CYP11A1-010
 
CYP11A1-011
 
CYP11A1-201
 
CYP11A1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP11A1-001 ENSP00000268053
ENST00000268053
P05108
Show all »
Show » Show » 521 60.1 No 0
CYP11A1-002 ENSP00000351455
ENST00000358632
P05108
Show all »
Show » Show » 363 42.2 No 0
CYP11A1-004 ENSP00000402064
ENST00000450547
C9JPU9
Show all »
Show » 96 10.8 No 0
CYP11A1-006 ENSP00000391081
ENST00000435365
E7EPP8
Show all »
Show » Show » 414 47.4 No 0
CYP11A1-008 ENSP00000388018
ENST00000416978
C9JXV4
Show all »
Show » 168 19 No 0
CYP11A1-010 ENSP00000456598
ENST00000569662
H3BS93
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Show » 27 3.1 No 0
CYP11A1-011 ENSP00000456941
ENST00000566674
H3BSZ1
Show all »
Show » Show » 227 26.1 No 0
CYP11A1-201 ENSP00000405488
ENST00000419019
P05108
Show all »
Show » Show » 363 42.2 No 0
CYP11A1-202 ENSP00000439750
ENST00000541301
F5H102
Show all »
Show » 144 16.4 No 0