CYP1A1

GENE INFORMATION

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Gene name

CYP1A1 (HGNC Symbol)

Synonyms

CP11, CYP1, P1-450, P450-C, P450DX

Description

cytochrome P450, family 1, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q24.1

Chromosome location (bp)

75011883 - 75017951

Ensembl

ENSG00000140465 (version 73.37)

Entrez gene

1543

UniProt

P04798 (UniProt - Evidence at protein level)

neXtProt

NX_P04798

Antibodypedia

CYP1A1 antibodies
 

PROTEIN VIEW

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CYP1A1-001
 
CYP1A1-002
 
CYP1A1-003
 
CYP1A1-004
 
CYP1A1-005
 
CYP1A1-006
 
CYP1A1-007
 
CYP1A1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP1A1-001 ENSP00000369050
ENST00000379727
P04798
Show all »
Show » Show » 512 58.2 No 0
CYP1A1-002 ENSP00000456585
ENST00000567032
P04798
Show all »
Show » Show » 512 58.2 No 0
CYP1A1-003 ENSP00000378489
ENST00000395049
E7EMT5
Show all »
Show » Show » 483 54.8 No 1
CYP1A1-004 ENSP00000457668
ENST00000564596
A4F3V9
Show all »
Show » Show » 157 18.4 No 1
CYP1A1-005 ENSP00000455051
ENST00000569630
A4F3W0
Show all »
Show » Show » 189 20.8 No 0
CYP1A1-006 ENSP00000455846
ENST00000566503
A4F3V8
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Show » Show » 175 20.6 No 0
CYP1A1-007 ENSP00000455340
ENST00000562201
A4F3W0
Show all »
Show » Show » 189 20.8 No 0
CYP1A1-201 ENSP00000378488
ENST00000395048
P04798
Show all »
Show » Show » 512 58.2 No 0