CYP1A2

GENE INFORMATION

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Gene name

CYP1A2 (HGNC Symbol)

Synonyms

CP12, P3-450

Description

cytochrome P450, family 1, subfamily A, polypeptide 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q24.1

Chromosome location (bp)

75041185 - 75048543

Ensembl

ENSG00000140505 (version 73.37)

Entrez gene

1544

UniProt

P05177 (UniProt - Evidence at protein level)

neXtProt

NX_P05177

Antibodypedia

CYP1A2 antibodies
 

PROTEIN VIEW

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CYP1A2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP1A2-001 ENSP00000342007
ENST00000343932
P05177
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