FURIN

GENE INFORMATION

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Gene name

FURIN (HGNC Symbol)

Synonyms

FUR, PACE, PCSK3, SPC1

Description

furin (paired basic amino acid cleaving enzyme) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q26.1

Chromosome location (bp)

91411822 - 91426688

Ensembl

ENSG00000140564 (version 73.37)

Entrez gene

5045

UniProt

P09958 (UniProt - Evidence at protein level)

neXtProt

NX_P09958

Antibodypedia

FURIN antibodies
 

PROTEIN VIEW

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FURIN-001
 
FURIN-002
 
FURIN-003
 
FURIN-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FURIN-001 ENSP00000268171
ENST00000268171
P09958
Show all »
Show » Show » 794 86.7 Yes 1
FURIN-002 ENSP00000453942
ENST00000558794
H0YNB5
Show all »
Show » Show » 216 23.1 No 0
FURIN-003 ENSP00000452730
ENST00000559353
H0YKB2
Show all »
Show » Show » 69 7.7 Yes 0
FURIN-005 ENSP00000453212
ENST00000560824
H0YLH7
Show all »
Show » Show » 175 19.8 Yes 0