FTO

GENE INFORMATION

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Gene name

FTO (HGNC Symbol)

Synonyms

KIAA1752, MGC5149

Description

fat mass and obesity associated (HGNC Symbol)

Entrez gene summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

Chromosome

16 (Chromosome progress)

Cytoband

q12.2

Chromosome location (bp)

53737875 - 54155853

Ensembl

ENSG00000140718 (version 73.37)

Entrez gene

79068

UniProt

Q9C0B1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9C0B1

Antibodypedia

FTO antibodies
 

PROTEIN VIEW

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FTO-001
 
FTO-002
 
FTO-003
 
FTO-005
 
FTO-006
 
FTO-008
 
FTO-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FTO-001 ENSP00000418823
ENST00000471389
Q9C0B1
Show all »
Show » 505 58.3 No 0
FTO-002 ENSP00000417422
ENST00000460382
Q9C0B1
Show all »
Show » 106 12.2 No 0
FTO-003 ENSP00000418424
ENST00000464071
F8WCB8
Show all »
Show » 70 8.3 No 0
FTO-005 ENSP00000417843
ENST00000463855
Q9C0B1
Show all »
Show » 127 14.9 No 0
FTO-006 ENSP00000415636
ENST00000431610
Q9C0B1
Show all »
Show » 106 12.2 No 0
FTO-008 ENSP00000268349
ENST00000268349
129 15 No 0
FTO-201 ENSP00000378142
ENST00000394647
B4DHN4
Show all »
Show » 209 24.3 No 0