ADAMTS18

GENE INFORMATION

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Gene name

ADAMTS18 (HGNC Symbol)

Synonyms

ADAMTS21

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 18 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

q23.1

Chromosome location (bp)

77281710 - 77469011

Ensembl

ENSG00000140873 (version 73.37)

Entrez gene

170692

UniProt

Q8TE60 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TE60

Antibodypedia

ADAMTS18 antibodies
 

PROTEIN VIEW

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ADAMTS18-001
 
ADAMTS18-002
 
ADAMTS18-009
 
ADAMTS18-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS18-001 ENSP00000282849
ENST00000282849
Q8TE60
Show all »
Show » Show » 1221 135.2 Yes 0
ADAMTS18-002 ENSP00000392540
ENST00000449265
B4DEX3
Show all »
Show » Show » 274 29.9 Yes 0
ADAMTS18-009 ENSP00000457395
ENST00000562345
Show » 186 20.9 No 0
ADAMTS18-011 ENSP00000454368
ENST00000562332
62 6.7 No 0