MBTPS1

GENE INFORMATION

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Gene name

MBTPS1 (HGNC Symbol)

Synonyms

KIAA0091, PCSK8, S1P, SKI-1

Description

membrane-bound transcription factor peptidase, site 1 (HGNC Symbol)

Entrez gene summary

The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

84087368 - 84150511

Ensembl

ENSG00000140943 (version 73.37)

Entrez gene

8720

UniProt

Q14703 (UniProt - Evidence at protein level)

neXtProt

NX_Q14703

Antibodypedia

MBTPS1 antibodies
 

PROTEIN VIEW

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MBTPS1-001
 
MBTPS1-009
 
MBTPS1-011
 
MBTPS1-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MBTPS1-001 ENSP00000344223
ENST00000343411
Q14703
Show all »
Show » Show » 1052 117.7 Yes 1
MBTPS1-009 ENSP00000456553
ENST00000569907
16 1.9 No 0
MBTPS1-011 ENSP00000457954
ENST00000570012
H3BV53
Show all »
Show » 146 16 No 0
MBTPS1-012 ENSP00000457508
ENST00000563231
Show » 81 8.7 No 0