ASGR1

GENE INFORMATION

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Gene name

ASGR1 (HGNC Symbol)

Synonyms

CLEC4H1

Description

asialoglycoprotein receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Chromosome

17 (Chromosome progress)

Cytoband

p13.1

Chromosome location (bp)

7076750 - 7082883

Ensembl

ENSG00000141505 (version 73.37)

Entrez gene

432

UniProt

P07306 (UniProt - Evidence at protein level)

neXtProt

NX_P07306

Antibodypedia

ASGR1 antibodies
 

PROTEIN VIEW

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ASGR1-001
 
ASGR1-002
 
ASGR1-007
 
ASGR1-008
 
ASGR1-009
 
ASGR1-010
 
ASGR1-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASGR1-001 ENSP00000269299
ENST00000269299
P07306
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Show » Show » 291 33.2 No 0
ASGR1-002 ENSP00000459169
ENST00000574388
P07306
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Show » 252 29.1 No 0
ASGR1-007 ENSP00000467511
ENST00000574330
I3L129
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Show » 162 18.4 No 0
ASGR1-008 ENSP00000370307
ENST00000380920
J3QSZ2
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Show » 190 22 No 0
ASGR1-009 ENSP00000458530
ENST00000572879
I3L129
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Show » 94 10.9 No 0
ASGR1-010 ENSP00000458803
ENST00000570576
I3L1F8
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Show » 30 3.5 No 0
ASGR1-011 ENSP00000459896
ENST00000573083
I3L2S9
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Show » Show » 117 13 No 0