TP53

GENE INFORMATION

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Gene name

TP53 (HGNC Symbol)

Synonyms

LFS1, p53

Description

tumor protein p53 (HGNC Symbol)

Entrez gene summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]

Chromosome

17 (Chromosome progress)

Cytoband

p13.1

Chromosome location (bp)

7565097 - 7590856

Ensembl

ENSG00000141510 (version 73.37)

Entrez gene

7157

UniProt

P04637 (UniProt - Evidence at protein level)

neXtProt

NX_P04637

Antibodypedia

TP53 antibodies
 

PROTEIN VIEW

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 « 
 
TP53-001
 
TP53-002
 
TP53-003
 
TP53-004
 
TP53-005
 
TP53-013
 
TP53-014
 
TP53-015
 
TP53-017
 
TP53-018
 
TP53-019
 
TP53-020
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TP53-001 ENSP00000269305
ENST00000269305
P04637
Show all »
Show » Show » 393 43.7 No 0
TP53-002 ENSP00000391478
ENST00000445888
P04637
Show all »
Show » Show » 393 43.7 No 0
TP53-003 ENSP00000426252
ENST00000503591
E9PCY9
Show all »
Show » Show » 128 13.7 No 0
TP53-004 ENSP00000398846
ENST00000455263
P04637
Show all »
Show » Show » 346 38.5 No 0
TP53-005 ENSP00000391127
ENST00000420246
P04637
Show all »
Show » Show » 341 37.8 No 0
TP53-013 ENSP00000423862
ENST00000514944
E9PFT5
Show all »
Show » Show » 155 17.7 No 0
TP53-014 ENSP00000424104
ENST00000508793
E7EMR6
Show all »
Show » Show » 165 17.8 No 0
TP53-015 ENSP00000425104
ENST00000509690
E7ESS1
Show all »
Show » Show » 199 22.5 No 0
TP53-017 ENSP00000458393
ENST00000576024
Show » 31 3.4 No 0
TP53-018 ENSP00000410739
ENST00000413465
E7EQX7
Show all »
Show » Show » 285 31.5 No 0
TP53-019 ENSP00000352610
ENST00000359597
J3KP33
Show all »
Show » Show » 343 37.9 No 0
TP53-020 ENSP00000473895
ENST00000604348
L0ES54
Show all »
Show » Show » 143 15.4 No 0