MBD1

GENE INFORMATION

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Gene name

MBD1 (HGNC Symbol)

Synonyms

CXXC3, PCM1

Description

methyl-CpG binding domain protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]

Chromosome

18 (Chromosome progress)

Cytoband

q21.1

Chromosome location (bp)

47793252 - 47808144

Ensembl

ENSG00000141644 (version 73.37)

Entrez gene

4152

UniProt

Q9UIS9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UIS9

Antibodypedia

MBD1 antibodies
 

PROTEIN VIEW

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 « 
 
MBD1-001
 
MBD1-002
 
MBD1-003
 
MBD1-004
 
MBD1-005
 
MBD1-007
 
MBD1-008
 
MBD1-009
 
MBD1-010
 
MBD1-011
 
MBD1-012
 
MBD1-013
 
MBD1-014
 
MBD1-016
 
MBD1-017
 
MBD1-024
 
MBD1-025
 
MBD1-026
 
MBD1-201
 
MBD1-202
 
MBD1-203
 
MBD1-204
 
MBD1-205
 
MBD1-206
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MBD1-001 ENSP00000381506
ENST00000398493
Q9UIS9
Show all »
Show » Show » 549 60 No 0
MBD1-002 ENSP00000269469
ENST00000353909
Q9UIS9
Show all »
Show » Show » 556 61.3 No 0
MBD1-003 ENSP00000381502
ENST00000398488
Q9UIS9
Show all »
Show » Show » 503 55.2 No 0
MBD1-004 ENSP00000467017
ENST00000591416
Q9UIS9
Show all »
Show » Show » 605 66.6 No 0
MBD1-005 ENSP00000372407
ENST00000382948
Q9UIS9
Show all »
Show » Show » 605 66.6 No 0
MBD1-007 ENSP00000468430
ENST00000585595
Q9UIS9
Show all »
Show » Show » 630 69.6 No 0
MBD1-008 ENSP00000466092
ENST00000585672
K7ELI2
Show all »
Show » 567 62.6 No 0
MBD1-009 ENSP00000467606
ENST00000592060
Show » 416 45.8 No 0
MBD1-010 ENSP00000339546
ENST00000339998
Q9UIS9
Show all »
Show » Show » 550 60.8 No 0
MBD1-011 ENSP00000468785
ENST00000590208
K7ESN0
Show all »
Show » 655 72.1 No 0
MBD1-012 ENSP00000468042
ENST00000587605
K7EQZ4
Show all »
Show » 535 58.8 No 0
MBD1-013 ENSP00000405268
ENST00000457839
Q9UIS9
Show all »
Show » Show » 630 69.6 No 0
MBD1-014 ENSP00000465923
ENST00000591535
Q9UIS9
Show all »
Show » Show » 536 59.2 No 0
MBD1-016 ENSP00000467763
ENST00000588937
Q9UIS9
Show all »
Show » Show » 586 64.7 No 0
MBD1-017 ENSP00000464823
ENST00000590215
K7EIN3
Show all »
Show » 44 5.1 No 0
MBD1-024 ENSP00000466806
ENST00000589541
K7EN65
Show all »
240 25.7 No 0
MBD1-025 ENSP00000466429
ENST00000589733
Show » 256 28.2 No 0
MBD1-026 ENSP00000381508
ENST00000398495
Show » 566 62.4 No 0
MBD1-201 ENSP00000269468
ENST00000269468
Q9UIS9
Show all »
Show » Show » 605 66.6 No 0
MBD1-202 ENSP00000269471
ENST00000269471
Q9UIS9
Show all »
Show » Show » 586 64.7 No 0
MBD1-203 ENSP00000285102
ENST00000347968
Q9UIS9
Show all »
Show » Show » 549 60 No 0
MBD1-204 ENSP00000342531
ENST00000349085
Q9UIS9
Show all »
Show » Show » 503 55.2 No 0
MBD1-205 ENSP00000408846
ENST00000424334
B4DI41
Show all »
Show » 656 72.4 No 0
MBD1-206 ENSP00000409561
ENST00000436910
Q9UIS9
Show all »
Show » Show » 536 59.2 No 0