SMAD4

GENE INFORMATION

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Gene name

SMAD4 (HGNC Symbol)

Synonyms

DPC4, MADH4

Description

SMAD family member 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009]

Chromosome

18 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

48494410 - 48611415

Ensembl

ENSG00000141646 (version 73.37)

Entrez gene

4089

UniProt

Q13485 (UniProt - Evidence at protein level)

neXtProt

NX_Q13485

Antibodypedia

SMAD4 antibodies
 

PROTEIN VIEW

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 « 
 
SMAD4-001
 
SMAD4-004
 
SMAD4-005
 
SMAD4-006
 
SMAD4-007
 
SMAD4-008
 
SMAD4-010
 
SMAD4-013
 
SMAD4-016
 
SMAD4-201
 
SMAD4-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMAD4-001 ENSP00000381452
ENST00000398417
Q13485
Show all »
Show » Show » 552 60.4 No 0
SMAD4-004 ENSP00000464901
ENST00000588745
K7EIU8
Show all »
Show » Show » 456 50.1 No 0
SMAD4-005 ENSP00000468611
ENST00000592186
K7ES96
Show all »
Show » Show » 320 35.1 No 0
SMAD4-006 ENSP00000466934
ENST00000589076
K7ENG1
Show all »
Show » Show » 91 9.9 No 0
SMAD4-007 ENSP00000464772
ENST00000590061
K7EIJ2
Show all »
Show » Show » 140 15.9 No 0
SMAD4-008 ENSP00000466941
ENST00000591914
K7ENG8
Show all »
Show » Show » 151 17 No 0
SMAD4-010 ENSP00000465874
ENST00000589941
K7EL15
Show all »
Show » Show » 120 13.7 No 0
SMAD4-013 ENSP00000466118
ENST00000593223
K7ELK2
Show all »
Show » Show » 82 8.6 No 0
SMAD4-016 ENSP00000465878
ENST00000588860
K7EL18
Show all »
Show » Show » 126 14.3 No 0
SMAD4-201 ENSP00000341551
ENST00000342988
Q13485
Show all »
Show » Show » 552 60.4 No 0
SMAD4-202 ENSP00000409551
ENST00000452201
L7N2F7
Show all »
Show » Show » 177 20.1 No 0