ERBB2

GENE INFORMATION

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Gene name

ERBB2 (HGNC Symbol)

Synonyms

CD340, HER-2, HER2, NEU, NGL

Description

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

37844167 - 37886679

Ensembl

ENSG00000141736 (version 73.37)

Entrez gene

2064

UniProt

P04626 (UniProt - Evidence at protein level)

neXtProt

NX_P04626

Antibodypedia

ERBB2 antibodies
 

PROTEIN VIEW

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ERBB2-001
 
ERBB2-003
 
ERBB2-004
 
ERBB2-005
 
ERBB2-007
 
ERBB2-008
 
ERBB2-011
 
ERBB2-012
 
ERBB2-013
 
ERBB2-015
 
ERBB2-018
 
ERBB2-019
 
ERBB2-201
 
ERBB2-202
 
ERBB2-203
 
ERBB2-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERBB2-001 ENSP00000462438
ENST00000584601
F5H1T4
Show all »
Show » Show » 1225 134.9 No 1
ERBB2-003 ENSP00000462808
ENST00000578199
F5H1T4
Show all »
Show » Show » 603 66.5 No 0
ERBB2-004 ENSP00000404047
ENST00000445658
B4DTR1
Show all »
Show » Show » 979 107.6 Yes 1
ERBB2-005 ENSP00000463714
ENST00000584450
J3QLU9
Show all »
Show » Show » 1055 117.1 Yes 1
ERBB2-007 ENSP00000463427
ENST00000578373
J3QL83
Show all »
Show » Show » 90 9.7 Yes 0
ERBB2-008 ENSP00000269571
ENST00000269571
P04626
Show all »
Show » Show » 1255 137.9 Yes 1
ERBB2-011 ENSP00000462024
ENST00000582648
J3KRI9
Show all »
Show » Show » 96 10.5 Yes 0
ERBB2-012 ENSP00000463719
ENST00000578709
J3QLV2
Show all »
Show » Show » 102 11.5 No 0
ERBB2-013 ENSP00000462270
ENST00000584099
J3KS21
Show all »
Show » Show » 139 15.6 No 0
ERBB2-015 ENSP00000464420
ENST00000578502
Show » Show » 166 18.1 No 0
ERBB2-018 ENSP00000463002
ENST00000580074
Q9NP09
Show all »
Show » Show » 251 27.7 No 1
ERBB2-019 ENSP00000464252
ENST00000582818
Q9NP09
Show all »
Show » 177 19.4 No 1
ERBB2-201 ENSP00000385185
ENST00000406381
F5H1T4
Show all »
Show » Show » 1225 134.9 No 1
ERBB2-202 ENSP00000446382
ENST00000540042
F5H1T4
Show all »
Show » Show » 603 66.5 No 0
ERBB2-203 ENSP00000443562
ENST00000540147
F5H1T4
Show all »
Show » Show » 1225 134.9 No 1
ERBB2-204 ENSP00000446466
ENST00000541774
P04626
Show all »
Show » Show » 1240 136.5 No 1