VAV1

GENERAL INFORMATION

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Gene name

VAV1

Gene description

Vav 1 guanine nucleotide exchange factor

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein localization

Moderate to strong cytoplasmic immunoreactivity was observed in most normal tissues. In the salivary gland only acinar epithelium was stained. Squamous epithelia were in general weaker stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA001864
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

VAV1 (HGNC Symbol)

Synonyms

VAV

Description

Vav 1 guanine nucleotide exchange factor (HGNC Symbol)

Entrez gene summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

6772714 - 6857366

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000141968 (version 78.38)

Entrez gene

7409

UniProt

P15498 (UniProt - Evidence at protein level)

neXtProt

NX_P15498

Antibodypedia

VAV1 antibodies


PROTEIN BROWSER

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ENST00000304076
 
ENST00000539284
 
ENST00000596764
 
ENST00000599806
 
ENST00000602142
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VAV1-001 ENSP00000472929
ENST00000602142
P15498
Show all »
Show » Show » 845 98.3 No 0
VAV1-002 ENSP00000302269
ENST00000304076
Show » Show » 823 95.8 No 0
VAV1-003 ENSP00000469450
ENST00000596764
P15498
Show all »
Show » Show » 813 94.5 No 0
VAV1-004 ENSP00000472803
ENST00000599806
Q96D37
Show all »
Show » Show » 790 92 No 0
VAV1-201 ENSP00000443242
ENST00000539284
Show » Show » 789 91.7 No 0