APP

GENE INFORMATION

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Gene name

APP (HGNC Symbol)

Synonyms

AD1

Description

Amyloid beta (A4) precursor protein (HGNC Symbol)

Entrez gene summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q21.3

Chromosome location (bp)

27252861 - 27543446

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142192 (version 75.37)

Entrez gene

351

UniProt

P05067 (UniProt - Evidence at protein level)

neXtProt

NX_P05067

Antibodypedia

APP antibodies
 

PROTEIN VIEW

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 « 
 
APP-001
 
APP-002
 
APP-003
 
APP-004
 
APP-005
 
APP-010
 
APP-011
 
APP-015
 
APP-016
 
APP-201
 
APP-202
 
APP-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APP-001 ENSP00000350578
ENST00000357903
P05067
Show all »
Show » Show » 751 84.8 Yes 1
APP-002 ENSP00000346129
ENST00000354192
P05067
Show all »
Show » Show » 639 72.6 Yes 1
APP-003 ENSP00000345463
ENST00000348990
P05067
Show all »
Show » Show » 695 78.7 Yes 1
APP-004 ENSP00000284981
ENST00000346798
P05067
Show all »
Show » Show » 770 86.9 Yes 1
APP-005 ENSP00000396923
ENST00000448850
Show » Show » 485 55 No 0
APP-010 ENSP00000406539
ENST00000415997
Show » 181 20.3 No 0
APP-011 ENSP00000397795
ENST00000456209
H7C104
Show all »
Show » Show » 280 31.9 No 0
APP-015 ENSP00000398879
ENST00000439274
E9PG40
Show all »
Show » Show » 714 80.8 Yes 1
APP-016 ENSP00000387483
ENST00000440126
P05067
Show all »
Show » Show » 746 84.5 No 1
APP-201 ENSP00000351796
ENST00000358918
P05067
Show all »
Show » Show » 752 85 Yes 1
APP-202 ENSP00000352760
ENST00000359726
P05067
Show all »
Show » Show » 714 80.8 Yes 1
APP-203 ENSP00000388538
ENST00000448388
E9PEV0
Show all »
Show » Show » 660 75.1 No 1