The Human Protein Atlas

GENE INFORMATION

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Gene name	APP (HGNC Symbol)
Synonyms	AD1
Description	amyloid beta (A4) precursor protein (HGNC Symbol)
Entrez gene summary	This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	21 (Chromosome progress)
Cytoband	q21.3
Chromosome location (bp)	27252861 - 27543446
Ensembl	ENSG00000142192 (version 69.37)
Entrez gene	351
UniProt	P05067
neXtProt	NX_P05067
Antibodypedia	APP antibodies

PROTEIN VIEW

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APP-001		APP-002		APP-003		APP-004		APP-005		APP-010		APP-011		APP-015		APP-201		APP-202		APP-203		APP-204

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
APP-001	ENSP00000350578 ENST00000357903	P05067 Show all » « Hide P05067 [Direct mapping] Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragm /.../ C31 B7Z313 [Target identity:37%; Query identity:100%] cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)	Show » « Hide Transporters Transporter channels and pores Plasma proteins Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000085 [G2 phase of mitotic cell cycle] GO:0001967 [suckling behavior] GO:0002576 [platelet degranulation] GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0005905 [coated pit] GO:0006378 [mRNA polyadenylation] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0006878 [cellular copper ion homeostasis] GO:0006897 [endocytosis] GO:0006917 [induction of apoptosis] GO:0007155 [cell adhesion] GO:0007176 [regulation of epidermal growth factor-activated receptor activity] GO:0007219 [Notch signaling pathway] GO:0007409 [axonogenesis] GO:0007596 [blood coagulation] GO:0007617 [mating behavior] GO:0007626 [locomotory behavior] GO:0008088 [axon cargo transport] GO:0008201 [heparin binding] GO:0008344 [adult locomotory behavior] GO:0008542 [visual learning] GO:0009986 [cell surface] GO:0016021 [integral to membrane] GO:0016199 [axon midline choice point recognition] GO:0016322 [neuron remodeling] GO:0016358 [dendrite development] GO:0016504 [peptidase activator activity] GO:0019717 [synaptosome] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030424 [axon] GO:0030900 [forebrain development] GO:0031093 [platelet alpha granule lumen] GO:0031175 [neuron projection development] GO:0031594 [neuromuscular junction] GO:0033130 [acetylcholine receptor binding] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035253 [ciliary rootlet] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0040014 [regulation of multicellular organism growth] GO:0042802 [identical protein binding] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0045177 [apical part of cell] GO:0045202 [synapse] GO:0045665 [negative regulation of neuron differentiation] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046914 [transition metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048669 [collateral sprouting in absence of injury] GO:0050803 [regulation of synapse structure and activity] GO:0050885 [neuromuscular process controlling balance] GO:0051124 [synaptic growth at neuromuscular junction] GO:0051233 [spindle midzone] GO:0051402 [neuron apoptotic process] GO:0051425 [PTB domain binding] GO:0051563 [smooth endoplasmic reticulum calcium ion homeostasis]	751	84.8	Yes	1
APP-002	ENSP00000346129 ENST00000354192	P05067 Show all » « Hide P05067 [Direct mapping] Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragm /.../ C31 B7Z313 [Target identity:43%; Query identity:100%] cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)	Show » « Hide Transporters Transporter channels and pores Plasma proteins Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000085 [G2 phase of mitotic cell cycle] GO:0001967 [suckling behavior] GO:0002576 [platelet degranulation] GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0005905 [coated pit] GO:0006378 [mRNA polyadenylation] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0006878 [cellular copper ion homeostasis] GO:0006897 [endocytosis] GO:0006917 [induction of apoptosis] GO:0007155 [cell adhesion] GO:0007176 [regulation of epidermal growth factor-activated receptor activity] GO:0007219 [Notch signaling pathway] GO:0007409 [axonogenesis] GO:0007596 [blood coagulation] GO:0007617 [mating behavior] GO:0007626 [locomotory behavior] GO:0008088 [axon cargo transport] GO:0008201 [heparin binding] GO:0008344 [adult locomotory behavior] GO:0008542 [visual learning] GO:0009986 [cell surface] GO:0016021 [integral to membrane] GO:0016199 [axon midline choice point recognition] GO:0016322 [neuron remodeling] GO:0016358 [dendrite development] GO:0016504 [peptidase activator activity] GO:0019717 [synaptosome] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030424 [axon] GO:0030900 [forebrain development] GO:0031093 [platelet alpha granule lumen] GO:0031175 [neuron projection development] GO:0031594 [neuromuscular junction] GO:0033130 [acetylcholine receptor binding] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035253 [ciliary rootlet] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0040014 [regulation of multicellular organism growth] GO:0042802 [identical protein binding] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0045177 [apical part of cell] GO:0045202 [synapse] GO:0045665 [negative regulation of neuron differentiation] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046914 [transition metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048669 [collateral sprouting in absence of injury] GO:0050803 [regulation of synapse structure and activity] GO:0050885 [neuromuscular process controlling balance] GO:0051124 [synaptic growth at neuromuscular junction] GO:0051233 [spindle midzone] GO:0051402 [neuron apoptotic process] GO:0051425 [PTB domain binding] GO:0051563 [smooth endoplasmic reticulum calcium ion homeostasis]	639	72.6	Yes	1
APP-003	ENSP00000345463 ENST00000348990	P05067 Show all » « Hide P05067 [Direct mapping] Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragm /.../ C31 E9PEV0 [Target identity:94%; Query identity:100%] Gamma-secretase C-terminal fragment 50 B7Z313 [Target identity:40%; Query identity:100%] cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)	Show » « Hide Transporters Transporter channels and pores Plasma proteins Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000085 [G2 phase of mitotic cell cycle] GO:0001967 [suckling behavior] GO:0002576 [platelet degranulation] GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0005905 [coated pit] GO:0006378 [mRNA polyadenylation] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0006878 [cellular copper ion homeostasis] GO:0006897 [endocytosis] GO:0006917 [induction of apoptosis] GO:0007155 [cell adhesion] GO:0007176 [regulation of epidermal growth factor-activated receptor activity] GO:0007219 [Notch signaling pathway] GO:0007409 [axonogenesis] GO:0007596 [blood coagulation] GO:0007617 [mating behavior] GO:0007626 [locomotory behavior] GO:0008088 [axon cargo transport] GO:0008201 [heparin binding] GO:0008344 [adult locomotory behavior] GO:0008542 [visual learning] GO:0009986 [cell surface] GO:0016021 [integral to membrane] GO:0016199 [axon midline choice point recognition] GO:0016322 [neuron remodeling] GO:0016358 [dendrite development] GO:0016504 [peptidase activator activity] GO:0019717 [synaptosome] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030424 [axon] GO:0030900 [forebrain development] GO:0031093 [platelet alpha granule lumen] GO:0031175 [neuron projection development] GO:0031594 [neuromuscular junction] GO:0033130 [acetylcholine receptor binding] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035253 [ciliary rootlet] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0040014 [regulation of multicellular organism growth] GO:0042802 [identical protein binding] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0045177 [apical part of cell] GO:0045202 [synapse] GO:0045665 [negative regulation of neuron differentiation] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046914 [transition metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048669 [collateral sprouting in absence of injury] GO:0050803 [regulation of synapse structure and activity] GO:0050885 [neuromuscular process controlling balance] GO:0051124 [synaptic growth at neuromuscular junction] GO:0051233 [spindle midzone] GO:0051402 [neuron apoptotic process] GO:0051425 [PTB domain binding] GO:0051563 [smooth endoplasmic reticulum calcium ion homeostasis]	695	78.7	Yes	1
APP-004	ENSP00000284981 ENST00000346798	P05067 Show all » « Hide P05067 [Direct mapping] Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragm /.../ C31 B7Z313 [Target identity:36%; Query identity:100%] cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)	Show » « Hide Transporters Transporter channels and pores Plasma proteins Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000085 [G2 phase of mitotic cell cycle] GO:0001967 [suckling behavior] GO:0002576 [platelet degranulation] GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005624 [membrane fraction] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0005905 [coated pit] GO:0006378 [mRNA polyadenylation] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0006878 [cellular copper ion homeostasis] GO:0006897 [endocytosis] GO:0006917 [induction of apoptosis] GO:0006979 [response to oxidative stress] GO:0007155 [cell adhesion] GO:0007176 [regulation of epidermal growth factor-activated receptor activity] GO:0007219 [Notch signaling pathway] GO:0007409 [axonogenesis] GO:0007596 [blood coagulation] GO:0007617 [mating behavior] GO:0007626 [locomotory behavior] GO:0008088 [axon cargo transport] GO:0008201 [heparin binding] GO:0008203 [cholesterol metabolic process] GO:0008344 [adult locomotory behavior] GO:0008542 [visual learning] GO:0009986 [cell surface] GO:0010468 [regulation of gene expression] GO:0010952 [positive regulation of peptidase activity] GO:0016021 [integral to membrane] GO:0016199 [axon midline choice point recognition] GO:0016322 [neuron remodeling] GO:0016358 [dendrite development] GO:0016504 [peptidase activator activity] GO:0019717 [synaptosome] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030424 [axon] GO:0030900 [forebrain development] GO:0031093 [platelet alpha granule lumen] GO:0031175 [neuron projection development] GO:0031410 [cytoplasmic vesicle] GO:0031594 [neuromuscular junction] GO:0033130 [acetylcholine receptor binding] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035253 [ciliary rootlet] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0040014 [regulation of multicellular organism growth] GO:0042802 [identical protein binding] GO:0043005 [neuron projection] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0043231 [intracellular membrane-bounded organelle] GO:0043393 [regulation of protein binding] GO:0045087 [innate immune response] GO:0045177 [apical part of cell] GO:0045202 [synapse] GO:0045665 [negative regulation of neuron differentiation] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046914 [transition metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048669 [collateral sprouting in absence of injury] GO:0050803 [regulation of synapse structure and activity] GO:0050885 [neuromuscular process controlling balance] GO:0051124 [synaptic growth at neuromuscular junction] GO:0051233 [spindle midzone] GO:0051402 [neuron apoptotic process] GO:0051425 [PTB domain binding] GO:0051563 [smooth endoplasmic reticulum calcium ion homeostasis]	770	86.9	Yes	1
APP-005	ENSP00000396923 ENST00000448850				485	55	No	0
APP-010	ENSP00000406539 ENST00000415997				181	20.3	No	0
APP-011	ENSP00000397795 ENST00000456209	H7C104 Show all » « Hide H7C104 [Target identity:100%; Query identity:100%] Gamma-secretase C-terminal fragment 50	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0016021 [integral to membrane]	308	35	No	1
APP-015	ENSP00000398879 ENST00000439274	E9PG40 Show all » « Hide E9PG40 [Target identity:100%; Query identity:100%] Gamma-secretase C-terminal fragment 50 B7Z313 [Target identity:38%; Query identity:100%] cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005794 [Golgi apparatus] GO:0008201 [heparin binding] GO:0016021 [integral to membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0046914 [transition metal ion binding]	714	80.8	Yes	1
APP-201	ENSP00000351796 ENST00000358918	P05067 Show all » « Hide P05067 [Direct mapping] Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragm /.../ C31	Show » « Hide Transporters Transporter channels and pores Plasma proteins Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000085 [G2 phase of mitotic cell cycle] GO:0001967 [suckling behavior] GO:0002576 [platelet degranulation] GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0005905 [coated pit] GO:0006378 [mRNA polyadenylation] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0006878 [cellular copper ion homeostasis] GO:0006897 [endocytosis] GO:0006917 [induction of apoptosis] GO:0007155 [cell adhesion] GO:0007176 [regulation of epidermal growth factor-activated receptor activity] GO:0007219 [Notch signaling pathway] GO:0007409 [axonogenesis] GO:0007596 [blood coagulation] GO:0007617 [mating behavior] GO:0007626 [locomotory behavior] GO:0008088 [axon cargo transport] GO:0008201 [heparin binding] GO:0008344 [adult locomotory behavior] GO:0008542 [visual learning] GO:0009986 [cell surface] GO:0016021 [integral to membrane] GO:0016199 [axon midline choice point recognition] GO:0016322 [neuron remodeling] GO:0016358 [dendrite development] GO:0016504 [peptidase activator activity] GO:0019717 [synaptosome] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030424 [axon] GO:0030900 [forebrain development] GO:0031093 [platelet alpha granule lumen] GO:0031175 [neuron projection development] GO:0031594 [neuromuscular junction] GO:0033130 [acetylcholine receptor binding] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035253 [ciliary rootlet] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0040014 [regulation of multicellular organism growth] GO:0042802 [identical protein binding] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0045177 [apical part of cell] GO:0045202 [synapse] GO:0045665 [negative regulation of neuron differentiation] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046914 [transition metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048669 [collateral sprouting in absence of injury] GO:0050803 [regulation of synapse structure and activity] GO:0050885 [neuromuscular process controlling balance] GO:0051124 [synaptic growth at neuromuscular junction] GO:0051233 [spindle midzone] GO:0051402 [neuron apoptotic process] GO:0051425 [PTB domain binding] GO:0051563 [smooth endoplasmic reticulum calcium ion homeostasis]	752	85	Yes	1
APP-202	ENSP00000352760 ENST00000359726	P05067 Show all » « Hide P05067 [Direct mapping] Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragm /.../ C31 B7Z313 [Target identity:38%; Query identity:100%] cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)	Show » « Hide Transporters Transporter channels and pores Plasma proteins Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000085 [G2 phase of mitotic cell cycle] GO:0001967 [suckling behavior] GO:0002576 [platelet degranulation] GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0005905 [coated pit] GO:0006378 [mRNA polyadenylation] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0006878 [cellular copper ion homeostasis] GO:0006897 [endocytosis] GO:0006917 [induction of apoptosis] GO:0007155 [cell adhesion] GO:0007176 [regulation of epidermal growth factor-activated receptor activity] GO:0007219 [Notch signaling pathway] GO:0007409 [axonogenesis] GO:0007596 [blood coagulation] GO:0007617 [mating behavior] GO:0007626 [locomotory behavior] GO:0008088 [axon cargo transport] GO:0008201 [heparin binding] GO:0008344 [adult locomotory behavior] GO:0008542 [visual learning] GO:0009986 [cell surface] GO:0016021 [integral to membrane] GO:0016199 [axon midline choice point recognition] GO:0016322 [neuron remodeling] GO:0016358 [dendrite development] GO:0016504 [peptidase activator activity] GO:0019717 [synaptosome] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030424 [axon] GO:0030900 [forebrain development] GO:0031093 [platelet alpha granule lumen] GO:0031175 [neuron projection development] GO:0031594 [neuromuscular junction] GO:0033130 [acetylcholine receptor binding] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035253 [ciliary rootlet] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0040014 [regulation of multicellular organism growth] GO:0042802 [identical protein binding] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0045177 [apical part of cell] GO:0045202 [synapse] GO:0045665 [negative regulation of neuron differentiation] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046914 [transition metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048669 [collateral sprouting in absence of injury] GO:0050803 [regulation of synapse structure and activity] GO:0050885 [neuromuscular process controlling balance] GO:0051124 [synaptic growth at neuromuscular junction] GO:0051233 [spindle midzone] GO:0051402 [neuron apoptotic process] GO:0051425 [PTB domain binding] GO:0051563 [smooth endoplasmic reticulum calcium ion homeostasis]	714	80.8	Yes	1
APP-203	ENSP00000387483 ENST00000440126	B4DII8 Show all » « Hide B4DII8 [Target identity:100%; Query identity:100%] Gamma-secretase C-terminal fragment 50; cDNA FLJ50531, highly similar to Amyloid beta A4 protein (APP) (ABPP)(Alzheimer disease amyloid protein homolog) B7Z313 [Target identity:37%; Query identity:100%] cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005794 [Golgi apparatus] GO:0008201 [heparin binding] GO:0016021 [integral to membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0046914 [transition metal ion binding]	746	84.5	No	1
APP-204	ENSP00000388538 ENST00000448388	E9PEV0 Show all » « Hide E9PEV0 [Target identity:100%; Query identity:100%] Gamma-secretase C-terminal fragment 50 B7Z313 [Target identity:42%; Query identity:100%] cDNA FLJ50525, highly similar to Amyloid beta A4 protein (APP) (ABPP) (Alzheimer disease amyloid protein homolog)	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0005794 [Golgi apparatus] GO:0008201 [heparin binding] GO:0016021 [integral to membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0046914 [transition metal ion binding]	660	75.1	No	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.