SLC6A3

GENERAL INFORMATION

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Gene name

SLC6A3

Gene description

Solute carrier family 6 (neurotransmitter transporter), member 3

Protein class

Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (thyroid gland)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

No internal RNA expression data available for correlation. Pending retesting on additional tissue.

Data reliability

Uncertain based on 2 antibodies.
HPA013602 , CAB016249
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (thyroid gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

SLC6A3 (HGNC Symbol)

Synonyms

DAT, DAT1

Description

Solute carrier family 6 (neurotransmitter transporter), member 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]

Chromosome

5

Cytoband

p15.33

Chromosome location (bp)

1392790 - 1445430

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142319 (version 78.38)

Entrez gene

6531

UniProt

Q01959 (UniProt - Evidence at protein level)

neXtProt

NX_Q01959

Antibodypedia

SLC6A3 antibodies


PROTEIN BROWSER

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ENST00000270349
 
ENST00000512002
 
ENST00000513308
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC6A3-001 ENSP00000270349
ENST00000270349
Q01959
Show all »
Show » Show » 620 68.5 No >9
SLC6A3-002 ENSP00000429101
ENST00000513308
H0YBA7
Show all »
Show » Show » 270 29.8 No 5
SLC6A3-003 ENSP00000430324
ENST00000512002
Show » 81 8.9 No 0