CAPN10

GENE INFORMATION

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Gene name

CAPN10

Synonyms

Description

calpain 10 (HGNC Symbol)

Entrez gene summary

Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

Chromosome

2 (Chromosome progress)

Cytoband

q37.3

Chromosome location (bp)

241526133 - 241557122

Ensembl

ENSG00000142330 (version 73.37)

Entrez gene

11132

UniProt

Q9HC96 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9HC96

Antibodypedia

CAPN10 antibodies
 

PROTEIN VIEW

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CAPN10-001
 
CAPN10-002
 
CAPN10-003
 
CAPN10-004
 
CAPN10-005
 
CAPN10-006
 
CAPN10-007
 
CAPN10-008
 
CAPN10-009
 
CAPN10-016
 
CAPN10-017
 
CAPN10-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAPN10-001 ENSP00000375844
ENST00000391984
Q9HC96
Show all »
Show » Show » 672 75 No 0
CAPN10-002 ENSP00000289381
ENST00000352879
Q9HC96
Show all »
Show » Show » 138 15.3 No 0
CAPN10-003 ENSP00000349556
ENST00000357048
Q9HC96
Show all »
Show » Show » 513 57.8 No 0
CAPN10-004 ENSP00000400144
ENST00000416591
Q9HC96
Show all »
Show » Show » 444 50 No 0
CAPN10-005 ENSP00000384422
ENST00000404753
B7WPF5
Show all »
Show » 653 72.9 No 0
CAPN10-006 ENSP00000270364
ENST00000270364
Q9HC96
Show all »
Show » Show » 139 15.6 No 0
CAPN10-007 ENSP00000270362
ENST00000354082
Q9HC96
Show all »
Show » Show » 517 58 No 0
CAPN10-008 ENSP00000270361
ENST00000270361
Q9HC96
Show all »
Show » Show » 274 29.5 No 0
CAPN10-009 ENSP00000375843
ENST00000391983
Q9HC96
Show all »
Show » Show » 544 60.7 No 0
CAPN10-016 ENSP00000404064
ENST00000426297
46 5 No 0
CAPN10-017 ENSP00000407090
ENST00000432084
H7C2P1
Show all »
Show » 79 8.8 No 0
CAPN10-201 ENSP00000375842
ENST00000391982
Q9HC96
Show all »
Show » Show » 444 50 No 0