KLK3

GENE INFORMATION

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Gene name

KLK3 (HGNC Symbol)

Synonyms

APS, PSA

Description

kallikrein-related peptidase 3 (HGNC Symbol)

Entrez gene summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.33

Chromosome location (bp)

51358171 - 51364020

Ensembl

ENSG00000142515 (version 73.37)

Entrez gene

354

UniProt

P07288 (UniProt - Evidence at protein level)

neXtProt

NX_P07288

Antibodypedia

KLK3 antibodies
 

PROTEIN VIEW

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 « 
 
KLK3-001
 
KLK3-002
 
KLK3-003
 
KLK3-006
 
KLK3-007
 
KLK3-010
 
KLK3-012
 
KLK3-013
 
KLK3-014
 
KLK3-015
 
KLK3-016
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KLK3-001 ENSP00000468912
ENST00000595392
M0QX57
Show all »
Show » Show » 124 13.9 Yes 0
KLK3-002 ENSP00000393628
ENST00000422986
Show » Show » 90 9.9 Yes 0
KLK3-003 ENSP00000314151
ENST00000326003
P07288
Show all »
Show » Show » 261 28.7 Yes 0
KLK3-006 ENSP00000471648
ENST00000596185
Q8WTQ8
Show all »
104 11.1 Yes 0
KLK3-007 ENSP00000353829
ENST00000360617
P07288
Show all »
Show » Show » 238 26.3 Yes 0
KLK3-010 ENSP00000472907
ENST00000593997
Q8IXI4
Show all »
Show » Show » 227 25.1 Yes 0
KLK3-012 ENSP00000472213
ENST00000601503
M0R1Z7
Show all »
Show » Show » 173 19.2 Yes 0
KLK3-013 ENSP00000470523
ENST00000597286
M0QZF9
Show all »
Show » Show » 172 19.1 Yes 0
KLK3-014 ENSP00000471827
ENST00000598145
Show » Show » 262 28.6 Yes 0
KLK3-015 ENSP00000471155
ENST00000595952
P07288
Show all »
Show » Show » 218 23.7 Yes 0
KLK3-016 ENSP00000472411
ENST00000597483
M0R294
Show all »
Show » Show » 195 21.3 Yes 0