PGD

GENERAL INFORMATION

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Gene name

PGD

Gene description

Phosphogluconate dehydrogenase

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Mainly cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA031314
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PGD

Synonyms

Description

Phosphogluconate dehydrogenase (HGNC Symbol)

Entrez gene summary

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.22

Chromosome location (bp)

10398592 - 10420144

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142657 (version 78.38)

Entrez gene

5226

UniProt

P52209 (UniProt - Evidence at protein level)

neXtProt

NX_P52209

Antibodypedia

PGD antibodies


PROTEIN BROWSER

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ENST00000270776
 
ENST00000460189
 
ENST00000465632
 
ENST00000483936
 
ENST00000491493
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PGD-001 ENSP00000270776
ENST00000270776
P52209
Show all »
Show » Show » 483 53.1 No 0
PGD-002 ENSP00000466358
ENST00000491493
K7EM49
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Show » Show » 205 22.3 No 0
PGD-006 ENSP00000466574
ENST00000465632
K7EMN2
Show all »
Show » Show » 160 17.3 No 0
PGD-007 ENSP00000466156
ENST00000483936
K7ELN9
Show all »
Show » Show » 224 24.8 No 0
PGD-008 ENSP00000467362
ENST00000460189
Show » Show » 256 27.8 No 0