CELA3A

GENE INFORMATION

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Gene name

CELA3A (HGNC Symbol)

Synonyms

ELA3, ELA3A

Description

chymotrypsin-like elastase family, member 3A (HGNC Symbol)

Entrez gene summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.12

Chromosome location (bp)

22328149 - 22339032

Ensembl

ENSG00000142789 (version 73.37)

Entrez gene

10136

UniProt

P09093 (UniProt - Evidence at protein level)

neXtProt

NX_P09093

Antibodypedia

CELA3A antibodies
 

PROTEIN VIEW

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CELA3A-001
 
CELA3A-002
 
CELA3A-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CELA3A-001 ENSP00000290122
ENST00000290122
P09093
Show all »
Show » Show » 270 29.5 Yes 0
CELA3A-002 ENSP00000363795
ENST00000374663
B1AQ52
Show all »
Show » Show » 121 13.2 Yes 0
CELA3A-004 ENSP00000383130
ENST00000400271
B1AQ55
Show all »
Show » 75 8.1 No 0