HSPG2

GENERAL INFORMATION

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Gene name

HSPG2

Gene description

Heparan sulfate proteoglycan 2

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Expression in cardiomyocytes, endothelial cells and a few other cell types. Positivity in extracellular matrix.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 3 antibodies.
HPA018892 , CAB009820 , CAB020718
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

HSPG2 (HGNC Symbol)

Synonyms

perlecan, PRCAN, SJS1

Description

Heparan sulfate proteoglycan 2 (HGNC Symbol)

Entrez gene summary

This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

1

Cytoband

p36.12

Chromosome location (bp)

21822245 - 21937297

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142798 (version 78.38)

Entrez gene

3339

UniProt

P98160 (UniProt - Evidence at protein level)

neXtProt

NX_P98160

Antibodypedia

HSPG2 antibodies


PROTEIN BROWSER

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ENST00000374673
 
ENST00000374676
 
ENST00000374695
 
ENST00000412328
 
ENST00000426143
 
ENST00000427897
 
ENST00000439717
 
ENST00000453796
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSPG2-001 ENSP00000363827
ENST00000374695
P98160
Show all »
Show » Show » 4391 468.8 Yes 0
HSPG2-003 ENSP00000405412
ENST00000412328
Q5SZI5
Show all »
Show » 239 25.9 No 0
HSPG2-004 ENSP00000363805
ENST00000374673
Show » Show » 180 19.5 No 0
HSPG2-005 ENSP00000395884
ENST00000439717
Q5SZJ2
Show all »
Show » 190 20.5 No 0
HSPG2-008 ENSP00000397573
ENST00000427897
Show » 197 20.4 No 0
HSPG2-010 ENSP00000363808
ENST00000374676
Show » 94 9.6 No 0
HSPG2-013 ENSP00000392022
ENST00000426143
Q5SZJ1
Show all »
Show » Show » 188 19.7 No 0
HSPG2-015 ENSP00000396310
ENST00000453796
Q5SZI9
Show all »
Show » Show » 207 22.1 No 0