BCL10

GENE INFORMATION

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Gene name

BCL10 (HGNC Symbol)

Synonyms

c-E10, CARMEN, CIPER, CLAP, mE10

Description

B-cell CLL/lymphoma 10 (HGNC Symbol)

Entrez gene summary

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p22.3

Chromosome location (bp)

85731931 - 85742773

Ensembl

ENSG00000142867 (version 73.37)

Entrez gene

8915

UniProt

O95999 (UniProt - Evidence at protein level)

neXtProt

NX_O95999

Antibodypedia

BCL10 antibodies
 

PROTEIN VIEW

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BCL10-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL10-001 ENSP00000359612
ENST00000370580
O95999
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